Healthcare >> CEO Interviews >> July 1, 1998

Stanley T. Crooke – Isis Pharmaceuticals (isip)

STANLEY T. CROOKE is Founder, Chairman and Chief Executive Officer of Isis Pharmaceuticals, Inc. Dr. Crooke is currently a member of the Board of Directors of Applied Molecular Evolutions, Inc., San Diego, California, EPIX Medical, Inc., Cambridge, Massachusetts; Idun Pharmaceuticals, Inc., La Jolla, California; Valentis, Inc., Burlingame, California; SYNSORB Biotech, Inc., Calgary, Alberta, Canada; and Axon Instruments, Inc., Foster City, California. He is a member of the IBC Advisory Council, Current Drugs Advisory Board, the Editorial Advisory Board of Journal of Drug Targeting and Antisense Research and Development, the Editorial Board of Gene Therapy and Molecular Biology. He is also Editor-in-Chief of Current Opinion in Anticancer Drugs and Section Editor for Biologicals and Immunologicals for Expert Opinion on Investigational Drugs. He has been appointed by the American Association for Cancer Research to serve as a member of the California State Legislative Committee. Prior to founding Isis, Dr. Crooke was President of Research and Development for SmithKline Beckman Corporation. He also coordinated the research and development activities of SKB including its instruments, diagnostics, animal health and clinical laboratory businesses. Prior to joining SKB, Dr. Crooke helped establish the anticancer drug discovery and development program at Bristol-Myers, which succeeded in bringing to market a significant number of drugs. In addition to his involvement in the pharmaceutical industry, Dr. Crooke also maintains active academic positions. He is an Adjunct Professor at University of California, San Diego and San Diego State University, and has won a number of teaching awards. He has authored over 415 publications and has edited 19 books. Dr. Crooke is active in molecular and cellular biology and pharmacology of antisense oligonucleotides. Profile
TWST: Give us a bit of an historical background on the company, and then

bring us up to date. What do you see over the next two to three years as

the key challenges and opportunities for ISIS?